Natural plant mucilage has gained importance over synthetic ones because of low toxicity, low cost and\r\ngood availability. The objective of the study was to search for a cheap and effective natural raw material\r\nthat can serve as an alternative suspending agent in the formulation of acetaminophen suspension. The\r\nphytochemical and the physicochemical properties of the mucilage of Ipomoea batatas L. were studied.\r\nThe suspending properties of mucilage extract of I. batatas L. were evaluated comparatively with that of\r\nacacia and sodium alginate using model formulations at concentrations of 5, 10, 15 and 20% w/v. The\r\nsuspensions were evaluated for rheological properties, sedimentation profile and stability studies. The\r\nresults showed the presence of flavonoids, saponin, protein, carbohydrate and reducing sugars. The\r\nrheological properties of suspension showed that increase in concentration increased the viscosity of\r\nsuspension, while increase in temperature did not significantly increased the viscosity of suspension (p\r\n< 0.05). The order of stability of suspension in terms of sedimentation profile ranked thus: E (20% w/v\r\npotato starch) > D (15% w/v potato starch) > F (10% w/v sodium alginate) > C (10% w/v potato starch) >\r\nB (5% w/v potato starch). These results indicate that mucilage from I. batatas L. in acetaminophen\r\nsuspension has low sedimentation rate, medium viscosity and easily dispersible and can therefore\r\nserve as suspending agent in formulations of suspensions of sparingly soluble drugs.
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